Welcome to The Amon Lab
The Amon Lab started in 1996 at the Whitehead Institute with Angelika Amon, Rosella Visintin and Susanne Prinz. In 1999 the lab moved to the Center for Cancer Research at MIT (now known as the The David Koch Institute for Integrative Cancer Reasearch at MIT) and has been there ever since. Currently, the lab consists of 9 Post Docs, 8 Graduate students, and 1 Technician.
The goal of our research is to obtain a detailed molecular understanding of the regulatory circuits that control chromosome segregation and what happens to cells in which these mechanisms fail and hence become aneuploid. We use the budding yeast S. cerevisiae as a model system to study chromosome segregation and the effects of aneuploidy on cell physiology, and probe discoveries made in yeast in the mouse.
Recent Publications
Tang YC, Williams BR, Siegel JJ, Amon A. Identification of aneuploidy-selective antiproliferation compounds. Cell. 2011 Feb 18; 144(4): 499-512.
Torres EM, Williams BR, Tang YC, Amon A. Thoughts on Aneuploidy. Cold Spring Harb Symp Quant Biol. 2011 Feb 2. [Epub ahead of print]
Torres EM, Dephoure N, Panneerselvam A, Tucker CM, Whittaker CA, Gygi SP, Dunham MJ, Amon A. Identification of Aneuploidy-Tolerating Mutations. Cell. 2010 Oct 1; 143(1): 71-83. Epub 2010 Sep 16.
Welcome to our new grad students!
