The Amon Lab started in 1996 at the Whitehead Institute with Angelika Amon, Rosella Visintin and Susanne Prinz. In 1999 the lab moved to the Center for Cancer Research at MIT (now known as the The David Koch Institute for Integrative Cancer Reasearch at MIT) and has been there ever since. Currently, the lab consists of 11 Post Docs, 10 Graduate students, and 1 Technician.
The goal of our research is to obtain a detailed molecular understanding of the regulatory circuits that control chromosome segregation and what happens to cells in which these mechanisms fail and hence become aneuploid. We use the budding yeast S. cerevisiae as a model system to study chromosome segregation and the effects of aneuploidy on cell physiology, and probe discoveries made in yeast in the mouse.
Rock JM, Amon A. Cdc15 integrates Tem1 GTPase-mediated spatial signals with Polo kinase-mediated temporal cues to activate mitotic exit. Genes Dev. 2011 Sep 15; 25(18): 1943-1954. PMCID: PMC3185966
Sheltzer JM, Amon A. The aneuploidy paradox: costs and benefits of an incorrect karyotype. Trends Genet. 2011 Nov; 27(11): 446-453. Epub 2011 Aug 26. PMCID: PMC3197822
van Werven FJ, Amon A. Regulation of entry into gametogenesis. Philos Trans R Soc Lond B Biol Sci. 2011 Dec 27; 366 (1584): 3521-3531. PMCID: PMC3203461
Congrats to Dr. Jeremy Rock on defending his thesis!